Sexually transmitted infections Pilot study suggests that PrEP for other STIs might work

Gus Cairns
Original Article:

A small pilot study using a daily dose of the antibiotic doxycycline as pre-exposure prophylaxis (PrEP) against sexually transmitted infections (STIs) has found that a group of HIV-positive gay men taking doxycycline was more than 70% less likely to be infected with an STI than men given financial incentives to avoid STIs, a significant difference. There were 76% fewer cases of syphilis, although the small size of the study meant that this difference was not statistically significant.

The authors suggest that “the use of daily doxycycline against syphilis an appropriate prevention tool…for a relatively small yet epidemiologically important population” of gay men. They add that the 77% overall retention rate in the pilot study “suggests that a clinical trial in a persistently high-risk group” of HIV-positive gay men “is feasible”.

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