The case for taking one pill a day to prevent HIV

Published: January 28, 2014

New global data overwhelmingly suggest that a pill to prevent HIV, approved by the United States’ Food and Drug Administration in July 2012, is safer and more effective than the medical community originally thought. Importantly, new models predict that when taken daily, the drug, called Truvada, can lower the risk of HIV transmission by 99 percent. Recent studies also show that a large-scale rollout of Truvada is unlikely to lead to increased antiviral drug resistance or risk-taking behavior, as some had feared.

But old concerns, even as they have been called into question, persist, and are hindering Truvada from being widely used for HIV prevention. This needs to change. 
The use of Truvada — a drug originally approved for HIV treatment — for HIV prevention in uninfected people is an unprecedented approach to addressing the epidemic. In the medical community, this form of therapy is known as Pre-Exposure Prophylaxis (PrEP) and so far Truvada is the only drug to obtain PrEP approval. While the US Centers for Disease Control and Prevention recommends PrEP for those at high risk for contracting HIV, such as men who have sex with men, sex workers, injection drug users, and people with known HIV-infected partners, its adoption has been slow over the last two years largely due to concerns about its safety, efficacy, and effect on patient’s sexual behavior.
When Truvada first was approved for PrEP, some public health experts and community groups feared that people might feel falsely protected against HIV and participate in high-risk sexual behavior, potentially negating the protective potential of the regimen. These critics also worried that mass prescription of PrEP could perpetuate antiviral drug resistance because of low adherence by patients in some studies. 
Complicating matters, physicians were hesitant to prescribe Truvada for PrEP because they felt its small risk of side effects and financial costs could be avoided if patients consistently used protective measures such as condoms and were careful in their choice and number of sexual partners. What’s more, the main study supporting the use of PrEP, known as the iPrEx Study, reported that PrEP worked only about half the time, confusing the health community, because it appeared PrEP was not as effective as expected.
Two years later, more recent studies tell a different story, but fears are still contributing to PrEP’s low support by physicians and low demand by at-risk patients. Ultimately, healthcare providers play a major role in patient decision-making and physicians need to stand behind PrEP so that patients will increase uptake and adherence.
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